Somatostatin receptors: localization and imagining methods (review)

Neuroendocrine tumors (NET) is a rare pathology characterized by dysfunction of the pituitary gland and endocrine glands. The survival prognosis depends on stage disease at which malignant growth was detected. study objective to summarize information methods early diagnosis NETs antitumor therapy using peptide hypothalamic hormone somatostatin analogues. review provides chronological analysis studies expression receptors (SSTRs) in different tissues organs, their visualization quantitative determination over 50 years. SSTRs revealed NET cell membranes. history dates back 1972, when first isolated its structure established. Later, therapeutic activity treatment NET, realized through receptors, discovered, number analogues were synthesized. Five main types are known, including subtypes expressed characteristic volumes corresponding pathologies. Determining staging neoplasms. Now regulation tumor carried out synthetic imaging an important planning with drugs this pharmacological group. Clinical various organs tissues, vitro vivo being out, for detecting studied compared. A retrospective used visualize diagnose treat presented. It has been shown that positron emission tomography combined computed tomography, SSTRs-binding radioligands safest most accurate method visualizing diagnosing NETs.